AustralieFrV1, Main, Exploration, bibRecord, 004566

Oral rivaroxaban versus standard therapy for the treatment of symptomatic venous thromboembolism: a pooled analysis of the EINSTEIN-DVT and PE randomized studies

Identifieur interne : 004566 ( Main/Exploration ); précédent : 004565; suivant : 004567

Oral rivaroxaban versus standard therapy for the treatment of symptomatic venous thromboembolism: a pooled analysis of the EINSTEIN-DVT and PE randomized studies

Auteurs : Martin H. Prins [Pays-Bas] ; Anthonie Wa Lensing [Allemagne] ; Rupert Bauersachs [Allemagne] ; Bonno Van Bellen [Brésil] ; Henri Bounameaux [Suisse] ; Timothy A. Brighton [Australie] ; Alexander T. Cohen [Royaume-Uni] ; Bruce L. Davidson [États-Unis] ; Hervé Decousus [France] ; Gary E. Raskob [États-Unis] ; Scott D. Berkowitz [États-Unis] ; Philip S. Wells [Canada]

Source :

Thrombosis Journal [ 1477-9560 ] ; 2013.

RBID : PMC:3850944

Abstract

Background

Standard treatment for venous thromboembolism (VTE) consists of a heparin combined with vitamin K antagonists. Direct oral anticoagulants have been investigated for acute and extended treatment of symptomatic VTE; their use could avoid parenteral treatment and/or laboratory monitoring of anticoagulant effects.

Methods

A prespecified pooled analysis of the EINSTEIN-DVT and EINSTEIN-PE studies compared the efficacy and safety of rivaroxaban (15 mg twice-daily for 21 days, followed by 20 mg once-daily) with standard-therapy (enoxaparin 1.0 mg/kg twice-daily and warfarin or acenocoumarol). Patients were treated for 3, 6, or 12 months and followed for suspected recurrent VTE and bleeding. The prespecified noninferiority margin was 1.75.

Results

A total of 8282 patients were enrolled; 4151 received rivaroxaban and 4131 received standard-therapy. The primary efficacy outcome occurred in 86 (2.1%) rivaroxaban-treated patients compared with 95 (2.3%) standard-therapy-treated patients (hazard ratio, 0.89; 95% confidence interval [CI], 0.66–1.19; p_{noninferiority} < 0.001). Major bleeding was observed in 40 (1.0%) and 72 (1.7%) patients in the rivaroxaban and standard-therapy groups, respectively (hazard ratio, 0.54; 95% CI, 0.37–0.79; p = 0.002). In key subgroups, including fragile patients, cancer patients, patients presenting with large clots, and those with a history of recurrent VTE, the efficacy and safety of rivaroxaban were similar compared with standard-therapy.

Conclusion

The single-drug approach with rivaroxaban resulted in similar efficacy to standard-therapy and was associated with a significantly lower rate of major bleeding. Efficacy and safety results were consistent among key patient subgroups.

Trial registration

EINSTEIN-PE: ClinicalTrials.gov, NCT00439777; EINSTEIN-DVT: ClinicalTrials.gov, NCT00440193.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850944

DOI: 10.1186/1477-9560-11-21
PubMed: 24053656
PubMed Central: 3850944

Affiliations:

Le document en format XML

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<region type="country">Angleterre</region>
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<author><name sortKey="Davidson, Bruce L" sort="Davidson, Bruce L" uniqKey="Davidson B" first="Bruce L" last="Davidson">Bruce L. Davidson</name>
<affiliation wicri:level="2"><nlm:aff id="I8">University of Washington School of Medicine, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Washington School of Medicine, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
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<author><name sortKey="Decousus, Herve" sort="Decousus, Herve" uniqKey="Decousus H" first="Hervé" last="Decousus">Hervé Decousus</name>
<affiliation wicri:level="3"><nlm:aff id="I9">Service de Médecine et Thérapeutique, CHU Saint-Etienne, Saint-Etienne, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Médecine et Thérapeutique, CHU Saint-Etienne, Saint-Etienne</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Saint-Étienne</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Raskob, Gary E" sort="Raskob, Gary E" uniqKey="Raskob G" first="Gary E" last="Raskob">Gary E. Raskob</name>
<affiliation wicri:level="2"><nlm:aff id="I10">University of Oklahoma Health Sciences Center, College of Public Health, Oklahoma City, OK, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Oklahoma Health Sciences Center, College of Public Health, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Berkowitz, Scott D" sort="Berkowitz, Scott D" uniqKey="Berkowitz S" first="Scott D" last="Berkowitz">Scott D. Berkowitz</name>
<affiliation wicri:level="2"><nlm:aff id="I11">Bayer HealthCare Pharmaceuticals, Whippany, NJ, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Bayer HealthCare Pharmaceuticals, Whippany, NJ</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
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<author><name sortKey="Wells, Philip S" sort="Wells, Philip S" uniqKey="Wells P" first="Philip S" last="Wells">Philip S. Wells</name>
<affiliation wicri:level="1"><nlm:aff id="I12">Department of Medicine, University of Ottawa and the Ottawa Hospital Research Institute, Ontario, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Medicine, University of Ottawa and the Ottawa Hospital Research Institute, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
</affiliation>
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<series><title level="j">Thrombosis Journal</title>
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<imprint><date when="2013">2013</date>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Standard treatment for venous thromboembolism (VTE) consists of a heparin combined with vitamin K antagonists. Direct oral anticoagulants have been investigated for acute and extended treatment of symptomatic VTE; their use could avoid parenteral treatment and/or laboratory monitoring of anticoagulant effects.</p>
</sec>
<sec><title>Methods</title>
<p>A prespecified pooled analysis of the EINSTEIN-DVT and EINSTEIN-PE studies compared the efficacy and safety of rivaroxaban (15 mg twice-daily for 21 days, followed by 20 mg once-daily) with standard-therapy (enoxaparin 1.0 mg/kg twice-daily and warfarin or acenocoumarol). Patients were treated for 3, 6, or 12 months and followed for suspected recurrent VTE and bleeding. The prespecified noninferiority margin was 1.75.</p>
</sec>
<sec><title>Results</title>
<p>A total of 8282 patients were enrolled; 4151 received rivaroxaban and 4131 received standard-therapy. The primary efficacy outcome occurred in 86 (2.1%) rivaroxaban-treated patients compared with 95 (2.3%) standard-therapy-treated patients (hazard ratio, 0.89; 95% confidence interval [CI], 0.66–1.19; p<sub>noninferiority</sub>
 < 0.001). Major bleeding was observed in 40 (1.0%) and 72 (1.7%) patients in the rivaroxaban and standard-therapy groups, respectively (hazard ratio, 0.54; 95% CI, 0.37–0.79; p = 0.002). In key subgroups, including fragile patients, cancer patients, patients presenting with large clots, and those with a history of recurrent VTE, the efficacy and safety of rivaroxaban were similar compared with standard-therapy.</p>
</sec>
<sec><title>Conclusion</title>
<p>The single-drug approach with rivaroxaban resulted in similar efficacy to standard-therapy and was associated with a significantly lower rate of major bleeding. Efficacy and safety results were consistent among key patient subgroups.</p>
</sec>
<sec><title>Trial registration</title>
<p>EINSTEIN-PE: ClinicalTrials.gov, <ext-link ext-link-type="uri" xlink:href="http://clinicaltrials.gov/show/NCT00439777">NCT00439777</ext-link>
; EINSTEIN-DVT: ClinicalTrials.gov, <ext-link ext-link-type="uri" xlink:href="http://clinicaltrials.gov/show/NCT00440193">NCT00440193</ext-link>
.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Silverstein, Md" uniqKey="Silverstein M">MD Silverstein</name>
</author>
<author><name sortKey="Heit, Ja" uniqKey="Heit J">JA Heit</name>
</author>
<author><name sortKey="Mohr, Dn" uniqKey="Mohr D">DN Mohr</name>
</author>
<author><name sortKey="Petterson, Tm" uniqKey="Petterson T">TM Petterson</name>
</author>
<author><name sortKey="O Allon, Wm" uniqKey="O Allon W">WM O’Fallon</name>
</author>
<author><name sortKey="Melton, Lj" uniqKey="Melton L">LJ Melton</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Oger, E" uniqKey="Oger E">E Oger</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Prandoni, P" uniqKey="Prandoni P">P Prandoni</name>
</author>
<author><name sortKey="Lensing, Aw" uniqKey="Lensing A">AW Lensing</name>
</author>
<author><name sortKey="Buller, Hr" uniqKey="Buller H">HR Buller</name>
</author>
<author><name sortKey="Carta, M" uniqKey="Carta M">M Carta</name>
</author>
<author><name sortKey="Cogo, A" uniqKey="Cogo A">A Cogo</name>
</author>
<author><name sortKey="Vigo, M" uniqKey="Vigo M">M Vigo</name>
</author>
<author><name sortKey="Casara, D" uniqKey="Casara D">D Casara</name>
</author>
<author><name sortKey="Ruol, A" uniqKey="Ruol A">A Ruol</name>
</author>
<author><name sortKey="Ten Cate, Jw" uniqKey="Ten Cate J">JW ten Cate</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Schulman, S" uniqKey="Schulman S">S Schulman</name>
</author>
<author><name sortKey="Kearon, C" uniqKey="Kearon C">C Kearon</name>
</author>
<author><name sortKey="Kakkar, Ak" uniqKey="Kakkar A">AK Kakkar</name>
</author>
<author><name sortKey="Mismetti, P" uniqKey="Mismetti P">P Mismetti</name>
</author>
<author><name sortKey="Schellong, S" uniqKey="Schellong S">S Schellong</name>
</author>
<author><name sortKey="Eriksson, H" uniqKey="Eriksson H">H Eriksson</name>
</author>
<author><name sortKey="Baanstra, D" uniqKey="Baanstra D">D Baanstra</name>
</author>
<author><name sortKey="Schnee, J" uniqKey="Schnee J">J Schnee</name>
</author>
<author><name sortKey="Goldhaber, Sz" uniqKey="Goldhaber S">SZ Goldhaber</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schulman, S" uniqKey="Schulman S">S Schulman</name>
</author>
<author><name sortKey="Kearon, C" uniqKey="Kearon C">C Kearon</name>
</author>
<author><name sortKey="Kakkar, Ak" uniqKey="Kakkar A">AK Kakkar</name>
</author>
<author><name sortKey="Schellong, S" uniqKey="Schellong S">S Schellong</name>
</author>
<author><name sortKey="Eriksson, H" uniqKey="Eriksson H">H Eriksson</name>
</author>
<author><name sortKey="Baanstra, D" uniqKey="Baanstra D">D Baanstra</name>
</author>
<author><name sortKey="Kvamme, Am" uniqKey="Kvamme A">AM Kvamme</name>
</author>
<author><name sortKey="Friedman, J" uniqKey="Friedman J">J Friedman</name>
</author>
<author><name sortKey="Mismetti, P" uniqKey="Mismetti P">P Mismetti</name>
</author>
<author><name sortKey="Goldhaber, Sz" uniqKey="Goldhaber S">SZ Goldhaber</name>
</author>
</analytic>
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<biblStruct><analytic><author><name sortKey="Agnelli, G" uniqKey="Agnelli G">G Agnelli</name>
</author>
<author><name sortKey="Buller, Hr" uniqKey="Buller H">HR Buller</name>
</author>
<author><name sortKey="Cohen, A" uniqKey="Cohen A">A Cohen</name>
</author>
<author><name sortKey="Curto, M" uniqKey="Curto M">M Curto</name>
</author>
<author><name sortKey="Gallus, As" uniqKey="Gallus A">AS Gallus</name>
</author>
<author><name sortKey="Johnson, M" uniqKey="Johnson M">M Johnson</name>
</author>
<author><name sortKey="Porcari, A" uniqKey="Porcari A">A Porcari</name>
</author>
<author><name sortKey="Raskob, Ge" uniqKey="Raskob G">GE Raskob</name>
</author>
<author><name sortKey="Weitz, Ji" uniqKey="Weitz J">JI Weitz</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Agnelli, G" uniqKey="Agnelli G">G Agnelli</name>
</author>
<author><name sortKey="Buller, Hr" uniqKey="Buller H">HR Buller</name>
</author>
<author><name sortKey="Cohen, A" uniqKey="Cohen A">A Cohen</name>
</author>
<author><name sortKey="Curto, M" uniqKey="Curto M">M Curto</name>
</author>
<author><name sortKey="Gallus, As" uniqKey="Gallus A">AS Gallus</name>
</author>
<author><name sortKey="Johnson, M" uniqKey="Johnson M">M Johnson</name>
</author>
<author><name sortKey="Masiukiewicz, U" uniqKey="Masiukiewicz U">U Masiukiewicz</name>
</author>
<author><name sortKey="Pak, R" uniqKey="Pak R">R Pak</name>
</author>
<author><name sortKey="Thompson, J" uniqKey="Thompson J">J Thompson</name>
</author>
<author><name sortKey="Raskob, Ge" uniqKey="Raskob G">GE Raskob</name>
</author>
<author><name sortKey="Weitz, Ji" uniqKey="Weitz J">JI Weitz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hutten, Ba" uniqKey="Hutten B">BA Hutten</name>
</author>
<author><name sortKey="Lensing, Aw" uniqKey="Lensing A">AW Lensing</name>
</author>
<author><name sortKey="Kraaijenhagen, Ra" uniqKey="Kraaijenhagen R">RA Kraaijenhagen</name>
</author>
<author><name sortKey="Prins, Mh" uniqKey="Prins M">MH Prins</name>
</author>
</analytic>
</biblStruct>
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</author>
<author><name sortKey="Lensing, Awa" uniqKey="Lensing A">AWA Lensing</name>
</author>
<author><name sortKey="Pap, A" uniqKey="Pap A">A Pap</name>
</author>
<author><name sortKey="Decousus, H" uniqKey="Decousus H">H Decousus</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Prandoni, P" uniqKey="Prandoni P">P Prandoni</name>
</author>
<author><name sortKey="Lensing, Awa" uniqKey="Lensing A">AWA Lensing</name>
</author>
<author><name sortKey="Piccioli, A" uniqKey="Piccioli A">A Piccioli</name>
</author>
<author><name sortKey="Bernardi, E" uniqKey="Bernardi E">E Bernardi</name>
</author>
<author><name sortKey="Simioni, P" uniqKey="Simioni P">P Simioni</name>
</author>
<author><name sortKey="Girolami, B" uniqKey="Girolami B">B Girolami</name>
</author>
<author><name sortKey="Marchiori, A" uniqKey="Marchiori A">A Marchiori</name>
</author>
<author><name sortKey="Sabbion, P" uniqKey="Sabbion P">P Sabbion</name>
</author>
<author><name sortKey="Prins, Mh" uniqKey="Prins M">MH Prins</name>
</author>
<author><name sortKey="Noventa, F" uniqKey="Noventa F">F Noventa</name>
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<author><name sortKey="Girolami, A" uniqKey="Girolami A">A Girolami</name>
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</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Prins, Mh" uniqKey="Prins M">MH Prins</name>
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<author><name sortKey="Lensing, Awa" uniqKey="Lensing A">AWA Lensing</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gail, M" uniqKey="Gail M">M Gail</name>
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<author><name sortKey="Simon, R" uniqKey="Simon R">R Simon</name>
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<author><name sortKey="Gallus, As" uniqKey="Gallus A">AS Gallus</name>
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<author><name sortKey="Gent, M" uniqKey="Gent M">M Gent</name>
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<author><name sortKey="Creemers Schild, D" uniqKey="Creemers Schild D">D Creemers-Schild</name>
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<author><name sortKey="Faber, Lm" uniqKey="Faber L">LM Faber</name>
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<author><name sortKey="Jonkers, Gj" uniqKey="Jonkers G">GJ Jonkers</name>
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<author><name sortKey="De Vreede, Mj" uniqKey="De Vreede M">MJ De Vreede</name>
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<author><name sortKey="Huisman, Mv" uniqKey="Huisman M">MV Huisman</name>
</author>
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</biblStruct>
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<author><name sortKey="Ten Cate, H" uniqKey="Ten Cate H">H Ten Cate</name>
</author>
<author><name sortKey="Buller, Hr" uniqKey="Buller H">HR Buller</name>
</author>
<author><name sortKey="Prins, Mh" uniqKey="Prins M">MH Prins</name>
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<author><name sortKey="Akl, Ea" uniqKey="Akl E">EA Akl</name>
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<author><name sortKey="Comerota, Aj" uniqKey="Comerota A">AJ Comerota</name>
</author>
<author><name sortKey="Prandoni, P" uniqKey="Prandoni P">P Prandoni</name>
</author>
<author><name sortKey="Bounameaux, H" uniqKey="Bounameaux H">H Bounameaux</name>
</author>
<author><name sortKey="Goldhaber, Sz" uniqKey="Goldhaber S">SZ Goldhaber</name>
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<author><name sortKey="Nelson, Me" uniqKey="Nelson M">ME Nelson</name>
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<author><name sortKey="Wells, Ps" uniqKey="Wells P">PS Wells</name>
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<author><name sortKey="Gould, Mk" uniqKey="Gould M">MK Gould</name>
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<author><name sortKey="Dentali, F" uniqKey="Dentali F">F Dentali</name>
</author>
<author><name sortKey="Crowther, M" uniqKey="Crowther M">M Crowther</name>
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<author><name sortKey="Kahn, Sr" uniqKey="Kahn S">SR Kahn</name>
</author>
</analytic>
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</div1>
</back>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Brésil</li>
<li>Canada</li>
<li>France</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
<li>Suisse</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Auvergne-Rhône-Alpes</li>
<li>District de Darmstadt</li>
<li>Grand Londres</li>
<li>Hesse (Land)</li>
<li>New Jersey</li>
<li>Oklahoma</li>
<li>Rhône-Alpes</li>
<li>Washington (État)</li>
<li>État de São Paulo</li>
</region>
<settlement><li>Darmstadt</li>
<li>Londres</li>
<li>Saint-Étienne</li>
<li>São Paulo</li>
</settlement>
</list>
<tree><country name="Pays-Bas"><noRegion><name sortKey="Prins, Martin H" sort="Prins, Martin H" uniqKey="Prins M" first="Martin H" last="Prins">Martin H. Prins</name>
</noRegion>
</country>
<country name="Allemagne"><noRegion><name sortKey="Lensing, Anthonie Wa" sort="Lensing, Anthonie Wa" uniqKey="Lensing A" first="Anthonie Wa" last="Lensing">Anthonie Wa Lensing</name>
</noRegion>
<name sortKey="Bauersachs, Rupert" sort="Bauersachs, Rupert" uniqKey="Bauersachs R" first="Rupert" last="Bauersachs">Rupert Bauersachs</name>
</country>
<country name="Brésil"><region name="État de São Paulo"><name sortKey="Van Bellen, Bonno" sort="Van Bellen, Bonno" uniqKey="Van Bellen B" first="Bonno" last="Van Bellen">Bonno Van Bellen</name>
</region>
</country>
<country name="Suisse"><noRegion><name sortKey="Bounameaux, Henri" sort="Bounameaux, Henri" uniqKey="Bounameaux H" first="Henri" last="Bounameaux">Henri Bounameaux</name>
</noRegion>
</country>
<country name="Australie"><noRegion><name sortKey="Brighton, Timothy A" sort="Brighton, Timothy A" uniqKey="Brighton T" first="Timothy A" last="Brighton">Timothy A. Brighton</name>
</noRegion>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Cohen, Alexander T" sort="Cohen, Alexander T" uniqKey="Cohen A" first="Alexander T" last="Cohen">Alexander T. Cohen</name>
</region>
</country>
<country name="États-Unis"><region name="Washington (État)"><name sortKey="Davidson, Bruce L" sort="Davidson, Bruce L" uniqKey="Davidson B" first="Bruce L" last="Davidson">Bruce L. Davidson</name>
</region>
<name sortKey="Berkowitz, Scott D" sort="Berkowitz, Scott D" uniqKey="Berkowitz S" first="Scott D" last="Berkowitz">Scott D. Berkowitz</name>
<name sortKey="Raskob, Gary E" sort="Raskob, Gary E" uniqKey="Raskob G" first="Gary E" last="Raskob">Gary E. Raskob</name>
</country>
<country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Decousus, Herve" sort="Decousus, Herve" uniqKey="Decousus H" first="Hervé" last="Decousus">Hervé Decousus</name>
</region>
</country>
<country name="Canada"><noRegion><name sortKey="Wells, Philip S" sort="Wells, Philip S" uniqKey="Wells P" first="Philip S" last="Wells">Philip S. Wells</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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Serveur d'exploration sur les relations entre la France et l'Australie

Oral rivaroxaban versus standard therapy for the treatment of symptomatic venous thromboembolism: a pooled analysis of the EINSTEIN-DVT and PE randomized studies

Oral rivaroxaban versus standard therapy for the treatment of symptomatic venous thromboembolism: a pooled analysis of the EINSTEIN-DVT and PE randomized studies

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	Serveur d'exploration sur les relations entre la France et l'Australie
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